In this article from thehorse.com vets, who are sworn to do no harm, INTENTIONALLY lamed eight Thoroughbreds to test a couple of drugs.
by: Nancy S. Loving, DVM
March 13 2012, Article # 19726
A common approach to lameness in the equine athlete is non-steroidal anti-inflammatory medications (NSAIDs) treatments, such as phenylbutazone (PBZ, Bute) or flunixin meglumine (FM, Banamine) alone or sometimes in combination. At the 2011 American Association of Equine Practitioners convention, held Nov. 18-22 in San Antonio, Jonathan Foreman, DVM, MS, Dipl. ACVIM, of the University of Illinois, discussed the effect of these medications on lameness when used at a normal recommended dose with these strategies and whether combining the drugs confers any special effects.
Reversible lameness was induced in eight Thoroughbred horses by using an adjustable heart bar shoe that could be tightened with a screw to elicit severe non-weight-bearing lameness. After an hour of the shoe application, Foreman and his colleagues treated the horses with one or both drugs: PBZ at 4.4 mg/kg, FM at 1.1 mg/kg, or PBZ + FM at these same dosages. In line with findings from previous studies, the team found that peak effect of these drugs occurred four hours following administration.